Journal
GELS
Volume 8, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/gels8050253
Keywords
apremilast; nanoemulsion; chitosan; gels; stability; anti-inflammatory; wound healing
Categories
Funding
- Deanship for Research and Innovation, Ministry of Education in Saudi Arabia [IF/PSAU-2021/03/18862]
Ask authors/readers for more resources
This study developed APL-loaded nanoemulsions using eucalyptus oil, Tween-80, and transcutol-HP as the oil, surfactant, and co-surfactant, respectively. The optimized nanoemulsion was incorporated into chitosan gel and exhibited significant anti-inflammatory and wound healing activity based on in vitro and in vivo studies.
Apremilast (APL) has profound anti-inflammatory and wound healing activity, alongside other dermal care. This study aims to develop APL-loaded NEs (ANE1-ANE5) using eucalyptus oil (EO) as the oil and Tween-80 and transcutol-HP (THP) as a surfactant and co-surfactant, respectively. The prepared NEs were then evaluated based on mean droplet size (12.63 +/- 1.2 nm), PDI (0.269 +/- 0.012), ZP (-23.00 +/- 5.86), RI (1.315 +/- 0.02), and %T (99.89 +/- 0.38) and ANE4 was optimized. Further, optimized NEs (ANE4) were incorporated into chitosan gel (2%, w/v). The developed ANE4-loaded chitosan gel was then evaluated for pH, spreadability, in vitro diffusion, and wound healing and anti-inflammatory studies. Moreover, in vivo studies denoted improved anti-inflammatory and wound healing activity and represented a decrease in wound size percentage (99.68 +/- 0.345%) for the APNE2 gel test compared to a negative control (86.48 +/- 0.87%) and standard control (92.82 +/- 0.34%). Thus, the formulation of ANE4-loaded chitosan gels is an efficient topical treatment strategy for inflammatory and wound healing conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available