Related references
Note: Only part of the references are listed.A text-based computational framework for patient -specific modeling for classification of cancers
Hiroaki Imoto et al.
ISCIENCE (2022)
PEtab-Interoperable specification of parameter estimation problems in systems biology
Leonard Schmiester et al.
PLOS COMPUTATIONAL BIOLOGY (2021)
Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface
Devan Diwanji et al.
NATURE (2021)
Deciphering the signaling network of breast cancer improves drug sensitivity prediction
Marco Tognetti et al.
CELL SYSTEMS (2021)
PIK3CA Mutations as a Molecular Target for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer
Nicola Fusco et al.
FRONTIERS IN ONCOLOGY (2021)
BioModels-15 years of sharing computational models in life science
Rahuman S. Malik-Sheriff et al.
NUCLEIC ACIDS RESEARCH (2020)
HER2-Low Breast Cancer: Pathological and Clinical Landscape
Paolo Tarantino et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
A Computational Framework for Prediction and Analysis of Cancer Signaling Dynamics from RNA Sequencing Data-Application to the ErbB Receptor Signaling Pathway
Hiroaki Imoto et al.
CANCERS (2020)
Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer
Simone Borgoni et al.
CANCERS (2020)
The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation
Babak Nami et al.
CANCERS (2019)
Extensions of l1 regularization increase detection specificity for cell-type specific parameters in dynamic models
Pascal Dolejsch et al.
BMC BIOINFORMATICS (2019)
Dynamic Modeling, Parameter Estimation, and Uncertainty Analysis in R
Daniel Kaschek et al.
JOURNAL OF STATISTICAL SOFTWARE (2019)
Clinical development of HER3-targeting monoclonal antibodies: Perils and progress
Wolfgang Jacob et al.
CANCER TREATMENT REVIEWS (2018)
Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
Pernilla Roswall et al.
NATURE MEDICINE (2018)
Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer
Sung-Young Shin et al.
PLOS COMPUTATIONAL BIOLOGY (2018)
Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer
Babak Nami et al.
CANCERS (2018)
Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation
Lorenz Adlung et al.
MOLECULAR SYSTEMS BIOLOGY (2017)
A comprehensive review of heregulins, HER3, and HER4 as potential therapeutic targets in cancer
Jose Mauricio Mota et al.
ONCOTARGET (2017)
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Ping Wee et al.
CANCERS (2017)
Predicting ligand-dependent tumors from multi-dimensional signaling features
Helge Hass et al.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS (2017)
Pertuzumab and trastuzumab: the rationale way to synergy
Sandrine Richard et al.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2016)
L1 regularization facilitates detection of cell type-specific parameters in dynamical systems
Bernhard Steiert et al.
BIOINFORMATICS (2016)
Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells
Ruth Merkle et al.
PLOS COMPUTATIONAL BIOLOGY (2016)
Driving the Model to Its Limit: Profile Likelihood Based Model Reduction
Tim Maiwald et al.
PLOS ONE (2016)
Customized Steady-State Constraints for Parameter Estimation in Non-Linear Ordinary Differential Equation Models
Marcus Rosenblatt et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
Zhan Yao et al.
CANCER CELL (2015)
The role of the insulin-like growth factor-1 system in breast cancer
Panagiotis F. Christopoulos et al.
MOLECULAR CANCER (2015)
Regulation of RAF protein kinases in ERK signalling
Hugo Lavoie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
The clinical and functional significance of c-Met in breast cancer: a review
Colan M. Ho-Yen et al.
BREAST CANCER RESEARCH (2015)
RPPanalyzer Toolbox: An improved R package for analysis of reverse phase protein array data
Silvia von der Heyde et al.
BIOTECHNIQUES (2014)
Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition
Milos Dokmanovic et al.
CANCER BIOLOGY & THERAPY (2014)
Subtyping of breast cancer using reverse phase protein arrays
Johanna Sonntag et al.
EXPERT REVIEW OF PROTEOMICS (2014)
The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor
Melanie K. B. Wills et al.
MOLECULAR BIOLOGY OF THE CELL (2014)
The ErbB/HER family of protein-tyrosine kinases and cancer
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2014)
Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy
Alexey Goltsov et al.
CELLS (2014)
Molecular determinants of trastuzumab efficacy: What is their clinical relevance?
Pradip De et al.
CANCER TREATMENT REVIEWS (2013)
Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines
Mario Niepel et al.
SCIENCE SIGNALING (2013)
Integration of Protein Abundance and Structure Data Reveals Competition in the ErbB Signaling Network
Christina Kiel et al.
SCIENCE SIGNALING (2013)
Targeting the ERBB family in cancer: couples therapy
Niall Tebbutt et al.
NATURE REVIEWS CANCER (2013)
Trastuzumab induces antibody-dependent cell-mediated cytotoxicity (ADCC) in HER-2-non-amplified breast cancer cell lines
D. M. Collins et al.
ANNALS OF ONCOLOGY (2012)
MEK1/2 dual-specificity protein kinases: Structure and regulation
Robert Roskoski
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Brian Magnuson et al.
BIOCHEMICAL JOURNAL (2012)
Targeting the EGFR signaling pathway in cancer therapy
Parthasarathy Seshacharyulu et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2012)
Dual Targeting of the Epidermal Growth Factor Receptor Using the Combination of Cetuximab and Erlotinib: Preclinical Evaluation and Results of the Phase II DUX Study in Chemotherapy-Refractory, Advanced Colorectal Cancer
Andrew J. Weickhardt et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Autocrine-Derived Epidermal Growth Factor Receptor Ligands Contribute to Recruitment of Tumor-Associated Macrophage and Growth of Basal Breast Cancer Cells In Vivo
Nicole K. Nickerson et al.
ONCOLOGY RESEARCH (2012)
Differential Effect of Growth Factors on Invasion and Proliferation of Endocrine Resistant Breast Cancer Cells
Maitham A. Khajah et al.
PLOS ONE (2012)
ERK1/2 MAP kinases: Structure, function, and regulation
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2012)
The ERBB network: at last, cancer therapy meets systems biology
Yosef Yarden et al.
NATURE REVIEWS CANCER (2012)
Akt signalling in health and disease
Ingeborg Hers et al.
CELLULAR SIGNALLING (2011)
RAF protein-serine/threonine kinases: Structure and regulation
Robert Roskoski
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Regularization Paths for Generalized Linear Models via Coordinate Descent
Jerome Friedman et al.
JOURNAL OF STATISTICAL SOFTWARE (2010)
Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood
A. Raue et al.
BIOINFORMATICS (2009)
Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Teemu T. Junttila et al.
CANCER CELL (2009)
Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab
Dana Faratian et al.
CANCER RESEARCH (2009)
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway
Sung-Young Shin et al.
JOURNAL OF CELL SCIENCE (2009)
Cell Type-Specific Importance of Ras-c-Raf Complex Association Rate Constants for MAPK Signaling
Christina Kiel et al.
SCIENCE SIGNALING (2009)
Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis
Birgit Schoeberl et al.
SCIENCE SIGNALING (2009)
A mathematical model for the effects of HER2 overexpression on cell proliferation in breast cancer
Amina Eladdadi et al.
BULLETIN OF MATHEMATICAL BIOLOGY (2008)
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
Elizabeth Iorns et al.
CANCER CELL (2008)
Targeted therapies for the treatment of breast cancer in the post-trastuzumab era
Fausto Petrelli et al.
ONCOLOGIST (2008)
Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy
Ido Amit et al.
MOLECULAR SYSTEMS BIOLOGY (2007)
Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses
Marc R. Birtwistle et al.
MOLECULAR SYSTEMS BIOLOGY (2007)
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis
M. M. Moasser
ONCOGENE (2007)
ErbB receptors: from oncogenes to targeted cancer therapies
Hongtao Zhang et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Combinatorial RNAi for quantitative protein network analysis
Ozgur Sahin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
Silvia D. M. Santos et al.
NATURE CELL BIOLOGY (2007)
Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity
Wanping Xu et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
Ogechi N. Ikediobi et al.
MOLECULAR CANCER THERAPEUTICS (2006)
EGF-ERBB signalling: towards the systems level
Ami Citri et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
ERBB receptors and cancer: The complexity of targeted inhibitors
NE Hynes et al.
NATURE REVIEWS CANCER (2005)
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
SQ Li et al.
CANCER CELL (2005)
Phosphotyrosine interactome of the ErbB-receptor kinase family
Waltraud X. Schulze et al.
MOLECULAR SYSTEMS BIOLOGY (2005)
Regularization and variable selection via the elastic net
H Zou et al.
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY (2005)
Regulation of raf-1 by direct feedback phosphorylation
MK Dougherty et al.
MOLECULAR CELL (2005)
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
MC Franklin et al.
CANCER CELL (2004)
Molecular portraits of breast cancer: tumour subtypes as distinct disease entities
T Sorlie
EUROPEAN JOURNAL OF CANCER (2004)
Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment
N Normanno et al.
ENDOCRINE-RELATED CANCER (2003)
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor α
TPJ Garrett et al.
CELL (2002)
Structure of the extracellular region of HER3 reveals an interdomain tether
HS Cho et al.
SCIENCE (2002)
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
B Schoeberl et al.
NATURE BIOTECHNOLOGY (2002)
Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor
NJ Hellyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The role of EGF-related peptides in tumor growth
N Normanno et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2001)
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.
DJ Slamon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Untangling the ErbB signalling network
Y Yarden et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
Share Paper
