Journal
CELL SYSTEMS
Volume 3, Issue 5, Pages 444-+Publisher
CELL PRESS
DOI: 10.1016/j.cels.2016.10.002
Keywords
-
Categories
Funding
- NIH [R01 GM097479, P50 HG002370, R01 GM086615]
- Simons Foundation
- MITRE
Ask authors/readers for more resources
Many cell signaling systems, including the yeast pheromone response system, exhibit ``dose-response alignment'' (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including `` push-pull'' mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available