Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 51, Pages 7128-7131Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc01996e
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Funding
- NSFC [22071210, 91956114]
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
- Shenzhen Science and Technology Innovation Committee [JCYJ20200109141408054]
- Natural Science Foundation of Jiangsu Province [BK20210849]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX21_2784]
- Innovation and Technology Commission [ITC-CNERC14SC01]
- Hong Kong Research Grants Council [16303420, 16309321]
- Innovation & Entrepreneurship Talents Plan of Jiangsu Province [JSSCRC2021536]
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A new organocatalytic asymmetric method for the synthesis of enantioenriched triarylmethanes has been developed, which employs asymmetric reduction via C-H bond formation as the key step, without requiring the presence of a heteroaryl ring or the presynthesis of unstable para-quinone methides.
A new organocatalytic asymmetric method for the synthesis of enantioenriched triarylmethanes is developed. Different from the conventional approaches featuring asymmetric arylation, the present study employs asymmetric reduction via C-H bond formation as the key step. This approach does not require the presence of a heteroaryl ring or the presynthesis of unstable para-quinone methides. Instead, the stable racemic triarylmethanols were used as substrates for the in situ generation of the intermediates with a suitable chiral phosphoric acid catalyst.
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