4.7 Article

Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Qing-zhang Tuo et al.

Summary: Ischemic stroke caused by arterial occlusion is a common type of stroke that involves multiple cell death pathways such as apoptosis, necroptosis, and autophagy. Understanding these pathways may reveal new neuroprotective interventions for ischemic stroke.

MEDICINAL RESEARCH REVIEWS (2022)

Article Oncology

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

Peng Liao et al.

Summary: T cell-derived interferon gamma (IFN γ) in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mechanism for CD8(+) T cell-mediated tumor killing. This process involves IFN γ stimulation of ACSL4 and alteration of tumor cell lipid pattern.

CANCER CELL (2022)

Article Geriatrics & Gerontology

ACSL4 contributes to ferroptosis-mediated rhabdomyolysis in exertional heat stroke

Sixiao He et al.

Summary: This study demonstrates the important role of ACSL4 in mediating ferroptosis activation in the development of RM following EHS. Inhibition of ACSL4 improves muscle cell death caused by EHS, thereby ameliorating RM development and suggesting a novel therapeutic strategy to limit skeletal muscle cell death and prevent RM after EHS.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2022)

Article Biochemistry & Molecular Biology

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Qing-zhang Tuo et al.

Summary: Ischemic stroke poses a significant threat to human health, especially among the elderly. This study suggests that thrombin, a serine protease, can initiate ferroptotic signaling in ischemic stroke. Inhibiting the thrombin-ACSL4 axis could be a potential therapeutic target for reducing neuronal injury in ischemic stroke.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

Article Cell Biology

Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

Jingjing Zhang et al.

Summary: The study suggests that upregulation and activation of YAP in astrocytes can prevent demyelination in EAE mice by suppressing the Hippo pathway. Deletion of YAP in astrocytes exacerbates EAE symptoms, with reduced expression of cholesterol-synthesis pathway genes like HMGCS1. Additionally, upregulation of cholesterol-synthesis pathways by DPN treatment or YAP activation by XMU-MP-1 treatment can partially rescue demyelination deficits in EAE mice.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

A harmonized atlas of mouse spinal cord cell types and their spatial organization

Daniel E. Russ et al.

Summary: Single-cell RNA sequencing data is used to generate a comprehensive cell atlas of mouse post-natal spinal cord, revealing the hierarchical relationships among cell types and providing spatial analysis of their distribution. Additionally, an open-source cell type classifier, SeqSeek, is developed to facilitate standardized cell type identification.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Transcranial Magnetic Stimulation Improves Muscle Involvement in Experimental Autoimmune Encephalomyelitis

Maria Angeles Pena-Toledo et al.

Summary: The study showed that transcranial magnetic stimulation (TMS) and natalizumab (NTZ) have beneficial effects on skeletal muscle involvement in the experimental autoimmune encephalomyelitis (EAE) model, with TMS demonstrating a superior myoprotective effect compared to NTZ.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Biochemistry & Molecular Biology

The essential elements of Alzheimer's disease

Peng Lei et al.

Summary: Despite numerous phase 3 clinical trials targeting amyloid plaque in AD treatment, their effectiveness remains uncertain. This study highlights the importance of other neurochemical abnormalities in the AD brain as potential therapeutic targets, focusing on elementomic signatures of essential elements like iron, copper, zinc, and selenium. Revisiting discoveries in the AD field may offer new insights into pathogenesis and therapeutic strategies.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Medicine, Research & Experimental

Myelin-specific CD8(+) T cells exacerbate brain inflammation in CNS autoimmunity

Catriona A. Wagner et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Oncology

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity

Iuliia Efimova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Biochemistry & Molecular Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang Li et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Review Immunology

PD-1 Tumor Suppressor Signaling in T Cell Lymphomas

Tim Wartewig et al.

TRENDS IN IMMUNOLOGY (2019)

Article Medicine, Research & Experimental

Potential role of iron in repair of inflammatory demyelinating lesions

Nathanael J. Lee et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Multidisciplinary Sciences

Opposing T cell responses in experimental autoimmune encephalomyelitis

Naresha Saligrama et al.

NATURE (2019)

Review Medicine, General & Internal

Multiple sclerosis

Alan J. Thompson et al.

LANCET (2018)

Article Multidisciplinary Sciences

Diversity of innate immune cell subsets across spatial and temporal scales in an EAE mouse model

Celine Caravagna et al.

SCIENTIFIC REPORTS (2018)

Article Immunology

TCR signal strength controls the differentiation of CD4+ effector and memory T cells

Jeremy P. Snook et al.

SCIENCE IMMUNOLOGY (2018)

Article Clinical Neurology

An updated histological classification system for multiple sclerosis lesions

Tanja Kuhlmann et al.

ACTA NEUROPATHOLOGICA (2017)

Article Urology & Nephrology

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI

Diego Martin-Sanchez et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Biochemistry & Molecular Biology

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-z Tuo et al.

MOLECULAR PSYCHIATRY (2017)

Article Medicine, Research & Experimental

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy

Christopher A. Klebanoff et al.

JCI INSIGHT (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Review Immunology

Dying cells actively regulate adaptive immune responses

Nader Yatim et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis

Itzy E. Morales Pantoja et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Immunology

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Mai Matsushita et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Review Clinical Neurology

Iron in multiple sclerosis: roles in neurodegeneration and repair

Erin Stephenson et al.

NATURE REVIEWS NEUROLOGY (2014)

Article Clinical Neurology

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

Scott Ayton et al.

ANNALS OF NEUROLOGY (2013)

Article Clinical Neurology

Iron and Neurodegeneration in the Multiple Sclerosis Brain

Simon Hametner et al.

ANNALS OF NEUROLOGY (2013)

Article Clinical Neurology

Disease-specific molecular events in cortical multiple sclerosis lesions

Marie Therese Fischer et al.

BRAIN (2013)

Article Biochemistry & Molecular Biology

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

Yichuan Xiao et al.

NATURE MEDICINE (2013)

Review Geriatrics & Gerontology

A delicate balance: Iron metabolism and diseases of the brain

Dominic Hare et al.

FRONTIERS IN AGING NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Immunology

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice

May H. Han et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Review Pharmacology & Pharmacy

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

Cris S. Constantinescu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Immunology

Increased expression of cystine/glutamate antiporter in multiple sclerosis

Olatz Pampliega et al.

JOURNAL OF NEUROINFLAMMATION (2011)

Article Medicine, Research & Experimental

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

Jose M. Gonzalez-Navajas et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Review Neurosciences

Oligodendrocytes and Myelination: The Role of Iron

Bozho Todorich et al.

Article Biochemistry & Molecular Biology

Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells

Ingunn M. Stromnes et al.

NATURE MEDICINE (2008)