Journal
MATERIALS ADVANCES
Volume 3, Issue 14, Pages 5778-5785Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ma00209d
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Funding
- AMED [JP20lm0203014]
- KAKENHI [JP19KK0277, JP20H02799]
- MEXT scholarship
- NAIST competitive research support
- NAIST Foreigner and woman incentive fund
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This study investigated the properties and surface coating performance of a urea-functionalized ester-free polymer PTMCM-SU. The modified polymer demonstrated higher glass transition temperature, improved wettability, and enhanced protein adsorption, suggesting its potential use as a coating surface for biomaterials.
As a contribution to future developments in biomaterials surface science, this study investigated the polymer properties and surface coating performance of urea-functionalized ester-free poly(trimethylene carbonate), 1-(2-mercaptoethyl)urea poly(trimethylene carbonate) (PTMCM-SU). An aromatic PTMC derivative bearing a vinyl moiety (PTMCM-VB) as a precursor was modified to PTMCM-SU via UV irradiation. In polymer design, hydrogen interaction may be induced in the PTMCM-SU by the presence of 1-(2-mercaptoethyl)urea (SU). Here, the glass transition temperature (T-g) of PTMCM-SU was increased to -2 degrees C compared to that of non-functionalized PTMC at -29 degrees C. The wettability of the polymer coatings on glass, stainless steel, and polyethylene (PE) was also studied. PTMC and PTMCM-VB had similar hydrophobic surfaces but the PTMCM-SU surface was hydrophilic. Interestingly, the protein adsorption on PTMCM-SU showed a higher affinity to the coated materials, thus enhancing their bioactivity. We demonstrated that, by modifying PTMC with a urea pendant, we could tune the polymer functionality and promote biological responsiveness for its potential use as a coating surface for biomaterials.
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