The Role of Pentraxin-3, Fetuin-A and Sirtuin-7 in the Diagnosis of Prostate Cancer

Purpose: Prostate cancer is the most commonly diagnosed type of cancer and one of the leading causes of can- cer-related death in men. Numerous efforts have been made to improve existing diagnostic methods and develop a new biomarker to identify patients with prostate cancer. In line with current literature, we preferred new se- rum-based biochemical markers as Pentraxin-3, Fetuin-A and Sirtuin-7 in the present study. Materials and Methods: A total of 174 patients aged 42-76 years were included in the study. Patients with pros- tate cancer (n = 38) were enrolled as Group 1 and patients with benign prostatic hyperplasia (n = 136) as Group 2. The serum levels of Pentraxin-3, Fetuin-A and Sirtuin-7 levels were compared between the groups. Results: The mean age of the patients was 61.9 ?? 7.6 years (p = .001). The mean serum Prostate Specific Antigen levels 32.0 ?? 59.6 (2.6-336) ng/mL and 10.0 ?? 11.3 (2.5-77.4) ng/mL in Group 1 and 2, respectively (p = .029). The mean serum levels of Pentraxin-3 and Fetuin-Ain Group 1 were statistically significantlydifferent from Group 2(3.3 ?? 4.4 ng/mL vs 1.8 ?? 2.4 ng/mL, p = .002 and 466.8 ?? 11.0 ??g/mL vs 513.3 ?? 11.0 ??g/mL, p = .041,respec- tively). There was no significant difference between Group 1 and 2 according to serum levels of Sirtuin-7 (12.7 ?? 8.2 ng/mL vs 12.7 ?? 12.4 ng/mL respectively, p = .145). Conclusion: Pentraxin-3, Fetuin-A and Sirtuin-7 may be effective in the diagnosis of prostate cancer in light of the current literature. In this study, it was found that Pentraxin-3 and Fetuin-A were significantly different in the diag- nosis of prostate cancer. Larger-scale prospective studies are needed to determine the importance of Pentraxin-3 and Fetuin-A in the diagnosis of prostate cancer.

Automated summary

This study investigated the diagnosis of prostate cancer and explored new biomarkers. The results showed that Pentraxin-3 and Fetuin-A were significantly different in the diagnosis of prostate cancer, suggesting their potential usefulness in diagnosis.