Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 19, Issue 5, Pages 952-964Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.62438
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Funding
- National Natural Science Foundation of China [NSFC 81601624]
- China Postdoctoral Science Foundation [2018M631028]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011233]
- 100 Talents Program of Sun Yat-Sen University [Y61216]
- First Affiliated Hospital, Sun Yat-sen University [Y70214]
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Preventing fibrosis or hypertrophic scar formation following tissue damage is still a challenge. This study reports the first successful case of scarless healing in a severe burn wound and discusses the mechanisms involved.
Y Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the perfect regenerative healing of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. We also discuss the mechanisms involved in the scarless healing of human burn wounds.
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