Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 53, Pages 7408-7411Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03051a
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Funding
- National Natural Science Foundation of China [21708019]
- Natural Science Foundation of Jiangsu [BK20170987]
- Nanjing Tech University [39837135]
- School Research Project of Jiangsu Health Vocational College [JKD202003]
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An azido pyridoxal derivative (PLAA) has been developed as a protein azidolation reagent with selectivity towards N-terminal glycine. It successfully modifies small peptides, natural proteins, and lab-expressed proteins under mild conditions, providing a unique method for post-synthesis site-specific azidolation of a peptide or protein.
An azido pyridoxal derivative (PLAA) was developed as a protein azidolation reagent, with selectivity towards N-terminal glycine. Successful PLAA modification was achieved with small peptides, natural proteins and lab-expressed proteins under mild conditions, offering a unique method for post-synthesis site-specific azidolation of a peptide or protein.
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