Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 53, Pages 7396-7399Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc02267b
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Funding
- National Natural Science Foundation of China [81925021, 81871500, 81921004]
- Science & Technology Project of Tianjin of China [18JCJQJC46900]
- National Key R&D Program of China [2018YFE0200503]
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A hybrid prodrug was synthesized to achieve the combined delivery of nitric oxide and hydrogen sulfide, providing effective treatment for heart failure post-myocardial infarction.
A hybrid prodrug was synthesized to realize the combined delivery of nitric oxide and hydrogen sulfide. The NO-H2S donor can release nitric oxide and hydrogen sulfide step by step in response to the endogenous enzymes beta-galactosidase and carbonic anhydrase, providing potent therapeutic efficacy for heart failure post- myocardial infarction.
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