Atom-economical, catalyst-free hydrosulfonation of densely functionalized alkenes: access to oxindole-containing sulfones

An atom-economical hydrosulfonation of densely functionalized alkenes under catalyst-free conditions is described. Alkenes possessing a hydroxy-oxindole moiety underwent hydrosulfonation on treatment with arylsulfinic acids in green media to afford the resulting sulfones in 72-86% yields with excellent diastereoselectivity.

Automated summary

This paper describes a catalyst-free hydrosulfonation reaction for densely functionalized alkenes. Alkenes with a hydroxy-oxindole moiety were reacted with arylsulfinic acids in green media, resulting in sulfones with yields of 72-86% and excellent diastereoselectivity.