4.8 Article

Synthesis of β-fluorocarboxylic esters via organophotoredox-catalyzed fluoroalkoxycarbonylation of alkenes in EtOH

Journal

GREEN CHEMISTRY
Volume 24, Issue 13, Pages 5077-5082

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2gc01609e

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Funding

  1. National Natural Science Foundation of China [21871053]
  2. Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2019R01005]
  3. Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University [2020ZD04]

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An efficient and environmentally friendly organophotoredox-catalyzed method has been developed for the synthesis of beta-fluorocarboxylic esters in EtOH. This approach allows the preparation of a variety of potential biologically active molecules containing both fluorine and ester functionalities.
An efficient and environmentally friendly organophotoredox-catalyzed method for the synthesis of beta-fluorocarboxylic esters with a broad substrate scope in EtOH has been developed. With this approach, a variety of potential biologically active molecules containing both fluorine and ester functionalities have been prepared.

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