Journal
POLYMER CHEMISTRY
Volume 13, Issue 27, Pages 4047-4053Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2py00397j
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Funding
- European Union [SUSPOL-EJD 642671]
- ERC [615142]
- EPSRC
- University of Birmingham
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We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. The introduction of cross-links and stimulus-sensitive nanostructures are achieved through post-polymerisation modification with various diamines. The stimuli-responsiveness of the nanoparticles towards a reducing agent and pH is evaluated by following the change in size using dynamic light scattering.
We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (l-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.
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