Journal
RSC ADVANCES
Volume 12, Issue 28, Pages 18209-18214Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra01141g
Keywords
-
Categories
Funding
- National Research Foundation of Korea (NRF) - Korean government [R-2018-00235]
- National Research Foundation of Korea (NRF) - Korea government [NRF-2018R1A5A2025964, NRF-2022R1A2C1011914]
- Technology Innovation Program (nano product performance safety evaluation technology development and business support project) - Ministry of Trade, Industry & Energy (MOTIE, Korea) [20014731]
- Korea Evaluation Institute of Industrial Technology (KEIT) [20014731] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
An amphipathic PAA-POSS@DOX drug delivery system that is sensitive to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). This system has high loading efficiency and can quickly release the drug to the target area, as confirmed by cell death in the MDA-MB-231 breast cancer line.
An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 +/- 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
