From main-chain conjugated polymer photosensitizer to hyperbranched polymer photosensitizer: expansion of the polymerization-enhanced photosensitization effect for photodynamic therapy

Three conjugated polymers that have the same donor-acceptor structure but totally different architectures are designed to show both Type-I and Type-II photosensitization abilities simultaneously, among which the hyperbranched polymer shows the best performance in both in vitro and in vivo experiments, superior to even the commonly used clinical photosensitizer of hemoporfin.

Automated summary

Three conjugated polymers with the same donor-acceptor structure but different architectures show both Type-I and Type-II photosensitization abilities simultaneously. Among them, the hyperbranched polymer demonstrates the best performance in both in vitro and in vivo experiments, surpassing the commonly used clinical photosensitizer hemoporfin.