4.6 Article

Haploidentical transplantation has a superior graft-versus-leukemia effect than HLA-matched sibling transplantation for Ph- high-risk B-cell acute lymphoblastic leukemia

Related references

Note: Only part of the references are listed.
Article Immunology

Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation

Huidong Guo et al.

Summary: Haploidentical stem cell transplantation (haplo-SCT) achieves superior clinical outcomes compared to HLA-matched sibling donor transplantation (MSDT) in treating hematological malignancies, largely due to the stronger graft-versus-leukemia activity induced by immune cells. This was demonstrated through both mouse models and a clinical trial involving patients with acute myeloid leukemia, highlighting the important role of immune cell dynamics in combating leukemia.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Oncology

Comparison of Two Strategies for Prophylactic Donor Lymphocyte Infusion in Patients With Refractory/Relapsed Acute Leukemia

Qiongqiong Su et al.

Summary: Delaying prophylactic donor lymphocyte infusion (pDLI) to day +90 based on minimal residual disease (MRD) for patients with refractory/relapsed acute leukemia undergoing allo-HSCT could reduce extensive chronic GVHD incidence and improve GVHD-free/relapse-free survival (GRFS) without increasing the risk of leukemia relapse.

FRONTIERS IN ONCOLOGY (2021)

Article Mathematical & Computational Biology

Practical recommendations for reporting Fine-Gray model analyses for competing risk data

Peter C. Austin et al.

STATISTICS IN MEDICINE (2017)

Review Oncology

How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Ying-Jun Chang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)

Editorial Material Hematology

Haploidentical transplantation: the search for the best donor

Rupert Handgretinger

BLOOD (2014)

Review Oncology

Acute Lymphoblastic Leukemia

Joseph C. Alvarnas et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2012)