Journal
RSC ADVANCES
Volume 12, Issue 29, Pages 18445-18449Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra03599e
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Funding
- School of Physics and Astronomy
- BBSRC [BB/N021150/1]
- University of Southampton
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In this study, we successfully demonstrated the rapid and accurate detection of SARS-CoV-2 infection without the need for PCR amplification using UCNPs and GO.
Since the beginning of the COVID-19 pandemic, there has been an increased need for the development of novel diagnostic solutions that can accurately and rapidly detect SARS-CoV-2 infection. In this work, we demonstrate the targeting of viral oligonucleotide markers within minutes without the requirement of a polymerase chain reaction (PCR) amplification step via the use of oligonucleotide-coated upconversion nanoparticles (UCNPs) and graphene oxide (GO).
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