Journal
SCIENCE BULLETIN
Volume 61, Issue 4, Pages 276-281Publisher
SCIENCE PRESS
DOI: 10.1007/s11434-016-1004-3
Keywords
Colorimetric; c-Myc mRNA; Peptide nucleic acid; Silver nanoparticles
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Funding
- National Natural Science Foundation of China [21305058, 21205056, 21075058, 21503104]
- Tai-Shan Scholar Research Fund of Shandong Province
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A label-free colorimetric protocol based on peptide nucleic acid/silver nanoparticles (PNA/AgNPs) has been initially proposed for specific recognition of mRNA. Making use of the controlled silver nanoparticles aggregation/dispersion by PNA/PNA-RNA complex, proto-oncogene c-Myc mRNA detection can be achieved. Moreover, the PNA/AgNPs platform can undergo color change in response to target c-Myc mRNA with single-base-mismatch sensitivity, which could further help in visually identify single nucleotide differences in target genes.
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