4.3 Review

Holmium-166 Radioembolization: Current Status and Future Prospective

Journal

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
Volume 45, Issue 11, Pages 1634-1645

Publisher

SPRINGER
DOI: 10.1007/s00270-022-03187-y

Keywords

Holmium-166; Radioembolization; Dosimetry; SPECT; CT; MRI

Funding

  1. NWO (Dutch Research Council) [NWA.ID.17.059]

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Since its suggestion as a possible option for liver radioembolization treatment, holmium-166 (Ho-166) has attracted attention due to its imaging possibilities and potential for individualized treatment. Ho-166 can be imaged using single-photon emission computed tomography and magnetic resonance imaging, and also allows for both scout and treatment procedures with the same particle.
Since its first suggestion as possible option for liver radioembolization treatment, the therapeutic isotope holmium-166 (Ho-166) caught the experts' attention due to its imaging possibilities. Being not only a beta, but also a gamma emitter and a lanthanide, Ho-166 can be imaged using single-photon emission computed tomography and magnetic resonance imaging, respectively. Another advantage of Ho-166 is the possibility to perform the scout and treatment procedure with the same particle. This prospect paves the way to an individualized treatment procedure, gaining more control over dosimetry-based patient selection and treatment planning. In this review, an overview on Ho-166 liver radioembolization will be presented. The current clinical workflow, together with the most relevant clinical findings and the future prospective will be provided.

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