Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 10, Issue 27, Pages 5218-5230Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb00687a
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Funding
- National Natural Science Foundation of China [51903023, 51825302, 21734002]
- Natural Science Foundation of Chongqing [cstc2021jcyj-cxttX0002, cstc2020jcyj-msxmX0140]
- Fundamental Research Funds for the Central Universities [2020CDJ-LHZZ-030]
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In this study, a composite scaffold was designed to recruit stem cells, stimulate osteogenic differentiation, and play a significant role in bone repair.
A scaffold is one of the most significant implants for treating bone injury, while the precise control of stem cell proliferation and differentiation within a scaffold is still challenging. In this work, a composite scaffold was designed to be capable of recruiting endogenous stem cells, stimulating osteogenic differentiation and achieving significant bone repair function. The designed SiCP + SF@PFS silica-calcium phosphate composite scaffold was obtained by mixing the peptide PFS containing silk fibroin solution with the SiCP scaffold, and treating with horseradish peroxidase and H2O2. The results showed that the composite scaffold was able to release the PFS peptide continuously to induce the migration of mesenchymal stem cells. Meanwhile, cell proliferation and osteogenic differentiation were also improved after being seeded on the scaffold. In the cranial defect rat model, the composite scaffold was able to recruit CD29(+) and CD90(+) cells one week after implantation around the injury sites. The results of Micro-CT, H&E staining, Masson's staining and immunohistochemical staining indicated that the composite scaffold was able to promote new bone formation significantly.
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