Journal
NON-CODING RNA
Volume 8, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ncrna8030040
Keywords
lncRNA; LINC00892; T cell activation; PD1; T helper cells; Follicular Lymphoma
Funding
- Kinderkrebsinitiative Buchholz, HolmSeppensen (KKI)
- DFG [SFB1074, B9]
- University of Kiel
Ask authors/readers for more resources
LINC00892, a non-coding transcript, is highly expressed in Jurkat cells following cell activation. Its expression pattern resembles genes involved in T cell memory and it is primarily expressed in effector memory and helper CD4+ T cell sub-types, but not in naive T cells. In situ analysis shows that LINC00892 is expressed in CD4+ PD1(hi) T cells, with a subcellular localization within the germinal center matching follicular helper T cells. Thus, LINC00892 could serve as a useful biomarker for detecting CD4+ memory T cells in both normal and tumor tissues.
Successful immunotherapy in both solid tumors and in hematological malignancies relies on the ability of T lymphocytes to infiltrate the cancer tissue and mount an immune response against the tumor. Biomarkers able to discern the amount and the types of T lymphocytes infiltrating a given tumor therefore have high diagnostic and prognostic value. Given that lncRNAs are known to have a highly cell-type-specific expression pattern, we searched for lncRNAs specifically expressed by activated T cells and at the same time in a kind of lymphoma, follicular lymphoma, where the microenvironment is known to play a critical role in the regulation of antitumor immunity. We focused on a non-coding transcript, annotated as LINC00892, which reaches extremely high expression levels following cell activation in Jurkat cells. Interestingly LINC00892 has an expression pattern resembling that of genes involved in T cell memory. Accordingly, LINC00892 is mostly expressed by the effector memory and helper CD4+ T cell sub-types but not by naive T cells. In situ analyses of LINC00892 expression in normal lymph nodes and in follicular lymphoma biopsies show that its expression is limited to CD4+ PD1(hi) T cells, with a subcellular localization within the germinal center matching that of follicular helper T cells. Our analysis therefore suggests that the previously uncharacterized lncRNA LINC00892 could be a useful biomarker for the detection of CD4+ memory T cells in both normal and tumor tissues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available