4.7 Article

The Influence of the Hydroxyl Type on Crosslinking Process in Cyclodextrin Based Polyurethane Networks

Journal

GELS
Volume 8, Issue 6, Pages -

Publisher

MDPI
DOI: 10.3390/gels8060348

Keywords

cyclodextrin; cyclodextrin-oligolactide; polyurethane; polyethylene glycol; biodegradable hydrogel; isophorone diisocyanate

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This study investigated the influence of hydroxyl group type on the polyaddition reactions of isocyanates and the structure/properties of resulting polyurethane hydrogels. By comparing native beta-cyclodextrin (CD) and its derivative esterified with oligolactide chains (CDLA), different networks were formed. The results show that the presence of primary hydroxyl groups leads to more compact networks with similar water uptake, while the predominance of secondary hydroxyl groups and the presence of oligolactide spacers allow for fine-tuning of the water swelling properties.
The influence of the hydroxyl groups (OH) type on the polyaddition processes of isocyanates represents a critical approach for the design of multicomponent polyurethane systems. Herein, to prove the effect of hydroxyl nature on both the isocyanate-OH polyaddition reactions and the structure/properties of the resulting networks, two structurally different cyclodextrins in terms of the primary and secondary groups' ratio were analyzed, namely native beta-cyclodextrin (CD) and its derivative esterified to the primary hydroxyl groups with oligolactide chains (CDLA). Thus, polyurethane hydrogels were prepared via the polyaddition of CD or CDLA to isophorone diisocyanate polyethylene glycol-based prepolymers (PEG-(NCO)(2)). The degradable character of the materials was induced by intercalating oligolactide short sequences into the polymer chains composing the polymer network. In order to establish the influence of the OH type, the synthesis of polyurethane hydrogels was analyzed by a rheological investigation of the overall system reactivity. Materials properties such as swelling behavior, thermal properties and hydrolytic degradation were influenced by the reaction feed. Specifically, the presence of primary OH groups leads to more compact networks with similar water uptake, disregarding the CD content, while the predominance of secondary OH groups together with the presence of oligolactide spacers leads to the fine tuning of the water swelling properties.

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