Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 15, Pages 4078-4084Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00473a
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Funding
- National Natural Science Foundation of China [21961018]
- Natural Science Foundation of Yunnan Province [201901T070302]
- Plan of Funding Outstanding Young Talents of Yunnan Province
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A cascade cyclization reaction of multi-component was reported, which can efficiently synthesize highly functionalized compounds. The reaction was conducted under mild conditions and showed good yields.
A multi-component cascade cyclization reaction of readily available 2,4-pentanediones, primary amines and sodium sulfinates is reported. Highly functionalized 5-alkylidene-3-pyrrolin-2-ones were efficiently synthesized in moderate to excellent yields under mild conditions. This cascade cyclization was achieved by direct regioselective transformation of C(sp(3))-H bonds at two weakly nucleophilic sites in the enaminone intermediate while two strongly nucleophilic sites of the structure were not involved.
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