Journal
EXPERT REVIEWS IN MOLECULAR MEDICINE
Volume 24, Issue -, Pages -Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/erm.2022.19
Keywords
AMPK; biomarker; FNDC5; irisin; liver disease; non-alcoholic fatty liver disease; PGC1 alpha
Ask authors/readers for more resources
In this review, the structure-function relationship of FNDC5/irisin is discussed, along with a comprehensive summary of its pathogenic roles and therapeutic applications in liver diseases. The underlying mechanisms and signaling pathways are also highlighted.
Fibronectin type III domain-containing protein 5 (FNDC5) is a transmembrane protein and the precursor of irisin, which serves as a systemic exerkine/myokine with multiple origins. Since its discovery in 2012, this hormone-like polypeptide has rapidly evolved to a component significantly involved in a gamut of metabolic dysregulations and various liver diseases. After a decade of extensive investigation on FNDC5/irisin, we are still surrounded by lots of open questions regarding its diagnostic and therapeutic values. In this review, we first concentrated on the structure-function relationship of FNDC5/irisin. Next, we comprehensively summarised the current knowledge and research findings regarding pathogenic roles/therapeutic applications of FNDC5/irisin in the context of non-alcoholic fatty liver disease, fibrosis, liver injury due to multiple detrimental insults, hepatic malignancy and intrahepatic cholestasis of pregnancy. Moreover, the prominent molecules involved in the underlying mechanisms and signalling pathways were highlighted. As a result, emerging evidence reveals FNDC5/irisin may act as a proxy for diagnosing liver disease pathology, a sensitive biomarker for assessing damage severity, a predisposing factor for surveilling illness progression and a treatment option with protective/preventive impact, all of which are highly dependent on disease grading and contextually pathological features.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available