Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 3, Issue 2, Pages 204-208Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5qo00319a
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Funding
- National Basic Research Program of China [2015CB856600]
- NSFC [21572201, 21422206, 21272206]
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A Pd-catalyzed arylation of lactic acid employing 8-aminoquinoline as the directing group has been reported. The protocol is found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral beta-aryl-alpha-hydroxy acids. Further, the new reaction has also been applied to the synthesis of pharmaceutically important a-hydroxy acids, such as LY519818 and tesaglitazar.
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