Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 3, Issue 2, Pages 222-226Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5qo00353a
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Funding
- Duke University
- National Science Foundation [CHE-1455220]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1455220] Funding Source: National Science Foundation
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Copper-catalyzed aminotrifluoromethylation of alkenes using amides as nucleophiles has been developed. It provides a rapid and efficient access to a variety of CF3-containing lactams. The reaction proceeds under mild conditions with a good scope and functional group tolerance, offering a valuable method to prepare CF3-containing lactams that are of great potential in pharmaceuticals and agrochemicals.
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