Synthesis of γ-amino acids via photocatalyzed intermolecular carboimination of alkenes

Primary gamma-amino acids are essential structural scaffolds with biological activity in pharmaceutical compounds. However, their preparation from readily available substrates remains challenging. Here, we report a direct approach to achieve the energy transfer-driven carboimination of alkenes for the synthesis of a diverse collection of valuable gamma-amino acids. Additionally, a variety of gamma-lactam derivatives are produced in only two steps from the simple substrates. Furthermore, this transformation features mild reaction conditions, operational simplicity, and excellent functional group tolerance.

Automated summary

This study presents a direct approach for the synthesis of a diverse collection of valuable gamma-amino acids, as well as a variety of gamma-lactam derivatives, from readily available substrates. The transformation features mild reaction conditions, operational simplicity, and excellent functional group tolerance.