4.4 Article

Holliday Cross-Recognition Protein HJURP: Association With the Tumor Microenvironment in Hepatocellular Carcinoma and With Patient Prognosis

Related references

Note: Only part of the references are listed.
Article Oncology

High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma

Jianjun Xu et al.

Summary: The study found that PPT1 is highly expressed in HCC and is associated with poor prognosis. The PPT1 inhibitor DC661 can enhance the sensitivity of HCC cells to sorafenib and enhance anti-tumor immune response by promoting immune cell activation. The combination of DC661 and sorafenib also shows good efficacy in tumor models in immunized mice.

CANCER CELL INTERNATIONAL (2022)

Article Cell Biology

HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer

Misha Mao et al.

Summary: This study focuses on the important role of the HJURP/YAP1/NDRG1 transcriptional regulation axis in triple-negative breast cancer. It found that HJURP affects the transcriptional activity of YAP1 and regulates cell proliferation and chemotherapy sensitivity by modulating the transcription of NDRG1 in triple-negative breast cancer.

CELL DEATH & DISEASE (2022)

Article Chemistry, Multidisciplinary

Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

Prachi Gupta et al.

Summary: SPHK1-packaged EVs increase S1P levels in the tumor microenvironment, leading to immunosuppression and promoting ovarian cancer progression. Inhibiting SPHK1/S1P signaling may enhance the efficacy of immune checkpoint blockade therapy in ovarian cancer.

ADVANCED SCIENCE (2022)

Article Immunology

HJURP is a prognostic biomarker for clear cell renal cell carcinoma and is linked to immune infiltration

Fan Zhang et al.

Summary: HJURP is upregulated in ccRCC, associated with poor pathological features and poor prognosis in patients. It serves as a high-risk factor for ccRCC patients and is closely linked to multiple immune-related signaling pathways.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Immunology

Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape

Yoshiko Takeuchi et al.

Summary: Highly mutated NSCLC with activation of the WNT/β-catenin pathway leads to impaired immune cell infiltration into the tumor microenvironment, resulting in resistance to PD-1 blockade therapy. Combination therapy with PD-1 blockade and WNT/β-catenin signaling inhibitors shows enhanced antitumor immunity compared to monotherapy.

SCIENCE IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Hypomethylation-driven overexpression of HJURP promotes progression of hepatocellular carcinoma and is associated with poor prognosis

Ye Li et al.

Summary: HJURP is identified as a crucial oncogene promoting HCC progression, with its high expression significantly associated with patient survival. HJURP enhances tumorigenesis through reducing cell arrest and increasing invasiveness in HCC.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Oncology

Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy

Stephen L. Shiao et al.

Summary: Studies have shown that intestinal fungi play a role in regulating antitumor immune responses following radiation in mouse models of breast cancer and melanoma. Fungi and bacteria have opposite influences on these responses, with depletion of fungi enhancing responsiveness to radiation while depletion of bacteria reducing responsiveness. Elevated intratumoral expression of Dectin-1, a primary innate sensor of fungi, is negatively associated with survival in breast cancer patients.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.
Article Cell Biology

HJURP promotes proliferation in prostate cancer cells through increasing CDKN1A degradation via the GSK3β/JNK signaling pathway

Wenjie Lai et al.

Summary: Genes with cross-cancer aberrations, such as HJURP, play a potential role in cancer progression and could serve as therapeutic targets. Higher expression of HJURP is associated with poorer outcomes in prostate cancer patients, and its mechanism involves promoting cell proliferation by regulating CDKN1A ubiquitination levels.

CELL DEATH & DISEASE (2021)

Article Immunology

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures

Dongqiang Zeng et al.

Summary: Recent advances in next-generation sequencing technologies have led to a rapid accumulation of publicly available multi-omics datasets. The development of IOBR as a computational tool aims to comprehensively interpret multi-omics data and facilitate immuno-oncology exploration for precision immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Tianzhi Wu et al.

Summary: The updated version of clusterProfiler 4.0 is a powerful tool for functional enrichment analysis in a wide range of organisms, offering tidy interfaces for data operation and visualization, as well as new features like gene set enrichment analysis and comparison of results from multiple gene lists.

INNOVATION (2021)

Review Biochemistry & Molecular Biology

Immuno-Metabolism and Microenvironment in Cancer: Key Players for Immunotherapy

Gaia Giannone et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma

Gaurav Sharma et al.

JCI INSIGHT (2020)

Article Biochemistry & Molecular Biology

Prognostic Relevance of HJURP Expression in Patients with Surgically Resected Colorectal Cancer

Dong Hyun Kang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma

Tianchi Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Oncology

T Cell Dysfunction in Cancer

Daniela S. Thommen et al.

CANCER CELL (2018)

Review Oncology

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy

Masahiro Shibata et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Article Cell Biology

Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP

Ewelina Zasadzinska et al.

DEVELOPMENTAL CELL (2018)

Review Biochemistry & Molecular Biology

PML control of cytokine signaling

Ghizlane Maarifi et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2014)

Article Geriatrics & Gerontology

HJURP Regulates Cellular Senescence in Human Fibroblasts and Endothelial Cells Via a p53-Dependent Pathway

Jong-Ik Heo et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)

Article Multidisciplinary Sciences

HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

Muhammad Shuaib et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

Elaine M. Dunleavy et al.

Article Biochemistry & Molecular Biology

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

Daniel R. Foltz et al.

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)