Journal
ONCOIMMUNOLOGY
Volume 5, Issue 7, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2016.1172153
Keywords
Blood-brain barrier; brain metastasis; immune checkpoint blockade; immunotherapy; tumor microenvironment
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Funding
- NATIONAL CANCER INSTITUTE [P01CA142538] Funding Source: NIH RePORTER
- NCI NIH HHS [P01 CA142538] Funding Source: Medline
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Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood-brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of the CNS will be crucial to forging therapeutic advances. In this review, the immunology of brain metastasis is explored.
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