Journal
ONCOIMMUNOLOGY
Volume 5, Issue 6, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1130207
Keywords
Adoptive T cell therapy; bacteria; macrophage; relapse; tumor stroma
Categories
Funding
- NIH [R01-CA37516, R01-CA22677, P01-CA97296]
- Graduate Training in Growth and Development grant [T32 HD009007]
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We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses and eradicates long-established tumors refractory to aCTLA-4 and aPD-L1 checkpoint inhibitor blockade. Here, we show that live intravenously injected or heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not producing tumor antigen, synergize with adoptive T cell therapy to eradicate tumors. These data demonstrate that the combination of adoptive T cell transfer with the injection of live or dead Salmonella typhimurium is a promising approach for cancer treatment.
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