Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 18, Issue 10, Pages 4260-4274Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.72251
Keywords
ferroptosis; iron metabolism; GSH; GPX4; lipid peroxidation; neurodegenerative diseases
Categories
Funding
- Public Welfare Research Project of Zhejiang Province [LGF20H220002]
- Medical and Health Science and Technology Project of Zhejiang Province [2021KY417]
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Ferroptosis is a novel type of cell death associated with cancer and neurodegenerative diseases. It can be selectively induced for cancer treatment or inhibited for neurodegenerative diseases.
Ferroptosis is a novel type of cell death characterized by iron-dependent lipid peroxidation that involves a variety of biological processes, such as iron metabolism, lipid metabolism, and oxidative stress. A growing body of research suggests that ferroptosis is associated with cancer and neurodegenerative diseases, such as glioblastoma, Alzheimer's disease, Parkinson's disease, and stroke. Building on these findings, we can selectively induce ferroptosis for the treatment of certain cancers, or we can treat neurodegenerative diseases by inhibiting ferroptosis. This review summarizes the relevant advances in ferroptosis, the regulatory mechanisms of ferroptosis, the participation of ferroptosis in brain tumors and neurodegenerative diseases, and the corresponding drug therapies to provide new potential targets for its treatment.
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