Journal
ACTA DIABETOLOGICA
Volume 59, Issue 9, Pages 1201-1208Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s00592-022-01923-x
Keywords
Obesity; Diabetes Mellitus type 2; Vitamin D; Fragility fractures; Osteoporosis
Categories
Funding
- CRUE-CSIC
- Springer Nature
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Obesity has negative effects on fracture risk, bone density, and vitamin D levels in postmenopausal women, and comorbid type 2 diabetes mellitus (T2DM) exacerbates these effects.
Aims To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. Methods 679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped into those with T2DM and those without. 25(OH)-vitamin D, PTH and BMD were measured, and prevalent fragility fractures were gathered. Results Obese women had higher prevalence of T2DM, than non-obese women. Levels of 25(OH)-vitamin D were lower and those of PTH higher in obese women, BMD values were higher in obese women. Diabetic-obese women had a higher prevalence of non-vertebral fractures than non-diabetic-obese. Multivariate logistic regression model showed association of fragility fractures with age, total hip BMD, BMI and T2DM. Obese women have higher BMD and lower 25(OH)-vitamin D values (and higher PTH) than non-obese, without diabetes. Conclusions T2DM confers an increased risk of non-vertebral fractures in postmenopausal obese women.
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