Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 61, Pages 8560-8563Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc02942a
Keywords
-
Categories
Funding
- China Scholarship Council (CSC) - FNRS PDR grant [T.0149.19 -T.262.20]
Ask authors/readers for more resources
In this study, a significant development in chiral resolution is presented. By varying the stoichiometry, both R- and S-enantiomers of mandelic acid were successfully separated from a racemic mixture using l-proline as a resolving agent. This specific feature is achieved through the existence of stoichiometrically diverse cocrystal systems between R- and S-mandelic acid and l-proline.
We present a thought-provoking development in chiral resolution. Using a resolving agent of a given handedness, l-proline, we show that both R- and S-enantiomers of mandelic acid can be resolved from a racemic mixture simply by varying the stoichiometry. We are the first to report this specific feature, achieved by the existence of stoichiometrically diverse cocrystal systems between R- and S-mandelic acid and l-proline.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available