Journal
JOURNAL OF MATERIALS CHEMISTRY C
Volume 10, Issue 29, Pages 10574-10585Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tc01348g
Keywords
-
Funding
- European Research Council (ERC) under the European Union [945945]
- Ghent University [BOF.STG.2020.0033.01]
- Research Foundation - Flanders (FWO) [G043219N, 1273621N, G099319N]
- European Research Council (ERC) [945945] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
The development of top-down hybrid rattle-shaped thermometers based on Hollow Periodic Mesoporous Organosilica (HPMO) and inorganic hosts is presented. These hybrid materials can efficiently emit lanthanide-based nanothermometers for potential use in future in vivo applications. Additionally, they have been shown to be non-toxic and can be used as a vehicle for drug delivery and release, potentially leading to a new generation of theranostic nanomaterials.
The development of top-down hybrid rattle-shaped thermometers based on Hollow Periodic Mesoporous Organosilica (HPMO) and either a beta-NaYF4 or a CaF2 inorganic host is presented in this work. We show that these kinds of hybrid materials allow preparing efficiently emitting lanthanide-based nanothermometers for potential use for future in vivo applications, where the thermometer is excited in the near-infrared region and emits in the visible or near-infrared region, in which human tissue is most transparent. The Yb-Er upconversion system and the tri-doped Yb-Er-Tm thermometry system were both explored. The hybrid materials were shown to be non-toxic to normal human dermal fibroblasts tested as an example of healthy human cells. The HPMO material, and further the hybrid HPMO@NaYF4:Er,Yb rattle structures, were also explored for drug loading and release ability using doxorubicin (DOX) as a model drug. This work shows that such HPMO-inorganic rattles can serve as a vehicle for drug delivery and release together with thermometry, potentially leading to a new generation of theranostic nanomaterials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available