Journal
JOURNAL OF ORTHOPAEDIC TRANSLATION
Volume 32, Issue -, Pages 121-129Publisher
ELSEVIER
DOI: 10.1016/j.jot.2022.02.001
Keywords
Osteoarthritis; Glucagon-like peptide-1 (GLP-1); Glucagon-like peptide-1 receptor (GLP-1R); Liraglutide; Cartilage; Synovial tissue
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This article reviews the GLP-1R pathway, molecular mechanisms, and phenotypes related to the pathogenesis of osteoarthritis (OA), and discusses the translational potential of GLP-1 analogues as disease-modifying therapies for OA due to their anti-inflammatory, immunoregulatory, and differentiation properties.
Osteoarthritis (OA) is a degenerative joint disease affecting millions of people worldwide. In OA, chondrocytes, synovial cells and other joint cells become activated when exposed to an abnormal environment, including mechanical stress, inflammatory cytokines or disorganization of matrix proteins. Several analogues of the hormones called incretins have been developed and are used notably for treating type 2 diabetes mellitus. Data has accumulated to suggest that incretinomimetics, which bind to the glucagon-like peptide-1 receptor (GLP-1R), have beneficial pleiotropic effects such as immunomodulation, anti-inflammation and neuronal protection. Thus, because of their anti-inflammatory properties, GLP-1-based therapies could benefit OA patients. This review focuses on the GLP-1R pathway, molecular mechanisms and phenotypes related to OA pathogenesis. The translational potential of this article: The search for new therapeutic targets to treat people suffering from OA remains urgent as there is currently no disease-modifyingtherapy available for this disease. This review discusses how GLP-1 analogues could be potential DMOADs for treating OA thanks to their anti-inflammatory, immunoregulatory and differentiation properties.
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