Journal
REACTION CHEMISTRY & ENGINEERING
Volume 7, Issue 9, Pages 1936-1944Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2re00153e
Keywords
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Funding
- ESF (European Social Fund)
- Chiral Technologies Europe
- Deutsche Forschungsgemeinschaft (DFG) [FOR 2177]
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A highly integrated microfluidic device is developed for parallel study of stereoselective heterogeneous catalytic processes. It combines multiple packed-bed mu-flow reactors with a chiral separation unit on a chip, seamlessly connected to mass spectrometry. The device allows automated fluidic setup and enables the study of different catalysts' performance using small amounts of resources.
A highly integrated microfluidic device is presented for the parallelised study of stereoselective heterogeneous catalytic processes. For the first time, multiple packed-bed mu-flow reactors are combined with a chiral separation unit on a chip that is seamlessly connected to mass spectrometry. By developing an automated fluidic setup, this device allows the performance of different catalysts to be studied in a single run, using only small amounts of resources. In this way, fully automated quasi-simultaneous testing of 2-packed bed reactors for enantioselectivity and conversion is possible, with a significant reduction in solvent and substrate consumption compared to classical tube reactor HPLC-MS testing.
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