Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 64, Pages 8958-8961Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc02648a
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Funding
- Czech Science Foundation [GA21-01799S]
- Ministry of Education, Youth and Sports [LM2018121]
- Operational Programme Research, Development and Education (the CETOCOEN EXCELLENCE project) [CZ.02.1.01/0.0/0.0/17_043/0009632]
- European Union [857560]
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In this study, we introduce carbon monoxide-photoreleasable compounds (photoCORMs) comprised of heptamethine cyanine and flavonol chromophores, which are activated by near-infrared light. These compounds exhibit excellent CO-release yields and uncaging cross sections in aqueous solutions, and their water solubility is enhanced through polar substituents or a host-guest approach using cucurbit[7]uril. Additionally, these hybrids demonstrate outstanding biocompatibility as well as diverse, structure-dependent cell penetrability and internalization.
Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization.
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