4.7 Article

Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes

Related references

Note: Only part of the references are listed.
Article Immunology

Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer

Yan Xu et al.

Summary: The study focused on utilizing allogeneic V gamma 9V delta 2 T cells for tumor immunotherapy, developing a novel formula for expanding gamma delta T cells from healthy donors, and conducting clinical trials to prove the safety and efficacy of allogeneic V gamma 9V delta 2 T cells, showing promising results in late-stage cancer patients.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Review Immunology

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

Yongyan Chen et al.

Summary: The liver is a lymphoid organ with unique immunological properties, and the balance between immune tolerance and immune activity is crucial for its physiological functions and sensitivity to diseases. Research on hepatic innate lymphocytes, including NK cells, ILC1/2/3s, NKT cells, gamma delta T cells, and MAIT cells, has become a focus, providing insights into their roles in liver homeostasis maintenance and disease progression. Understanding the immunopathogenesis of hepatic innate lymphocytes may lead to more effective treatments for liver diseases and cancer.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Immunology

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Noella Lopes et al.

Summary: Different subsets of γδ T cells, including IFN-γ(+) and IL-17(+) cells, have distinct metabolic requirements and characteristics. These metabolic signatures are imprinted early during thymic development and have implications for tumor development and immunotherapy.

NATURE IMMUNOLOGY (2021)

Article Cell Biology

Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer

Emelie Foord et al.

Summary: Studies have shown that gamma delta T cells in patients with advanced epithelial ovarian cancer exhibit different TCR diversity and clonality between tumor-infiltrating cells and ascites-derived cells, suggesting different activation pathways at tumor sites. High gamma delta T cell cytokine responsiveness is associated with favorable patient outcomes in terms of survival and reduced residual tumor burden after surgery. Additionally, the proportions of CD39-expressing T cells negatively affect gamma delta T cell functionality and patient survival, highlighting the potential of CD39 as a target for improving gamma delta T cell responses.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Immunology

Cancer immunotherapy with γδ T cells: many paths ahead of us

Dieter Kabelitz et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus

Yujun Pei et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Medicine, Research & Experimental

Metabolism in tumor microenvironment: Implications for cancer immunotherapy

Rongchen Shi et al.

MEDCOMM (2020)

Review Cell Biology

NK cell metabolism

Clair M. Gardiner

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Review Immunology

Role of innate immune cells in metabolism: from physiology to type 2 diabetes

Elise Dalmas

SEMINARS IN IMMUNOPATHOLOGY (2019)

Review Immunology

γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance

Adrian C. Hayday

JOURNAL OF IMMUNOLOGY (2019)

Review Oncology

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

Bruno Silva-Santos et al.

NATURE REVIEWS CANCER (2019)

Article Immunology

Functional status of immune cells in patients with long-lasting type 2 diabetes mellitus

H. W. Nam et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Letter Medicine, General & Internal

Metformin as first-line treatment for type 2 diabetes

Suetonia C. Palmer et al.

LANCET (2018)

Review Immunology

Signals Controlling Lytic Granule Polarization at the Cytotoxic immune Synapse

Anna Kabanova et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Endocrinology & Metabolism

AMPK activation by A-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes

Franziska Kopietz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2018)

Review Pharmacology & Pharmacy

Metformin as an Anticancer Agent

Ales Vancura et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Review Endocrinology & Metabolism

Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus

Tong Zhou et al.

JOURNAL OF DIABETES RESEARCH (2018)

Review Immunology

Macrophage Immunometabolism: Where Are We (Going)?

Jan Van den Bossche et al.

TRENDS IN IMMUNOLOGY (2017)

Review Endocrinology & Metabolism

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Chang Xia et al.

JOURNAL OF DIABETES RESEARCH (2017)

Review Oncology

Metformin: A Bridge between Diabetes and Prostate Cancer

Veronica Zingales et al.

FRONTIERS IN ONCOLOGY (2017)

Review Immunology

γδ T cells in homeostasis and host defence of epithelial barrier tissues

Morten M. Nielsen et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Oncology

Type 2 Diabetes Mellitus and Cancer: The Role of Pharmacotherapy

Gadi Shlomai et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Review Pharmacology & Pharmacy

Serendipity in Cancer Drug Discovery: Rational or Coincidence?

Sandeo Prasad et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Review Immunology

Origins of the cytolytic synapse

Maike de la Roche et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Review Biochemistry & Molecular Biology

Regulation and function of AMPK in physiology and diseases

Sang-Min Jeon

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Metabolic regulation of natural killer cells

David K. Finlay

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

Editorial Material Cell Biology

Metformin Action: Concentrations Matter

Ling He et al.

CELL METABOLISM (2015)

Editorial Material Endocrinology & Metabolism

Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK

N. Holman et al.

DIABETIC MEDICINE (2015)

Article Biochemistry & Molecular Biology

Glucose, glycolysis and lymphocyte responses

Raymond P. Donnelly et al.

MOLECULAR IMMUNOLOGY (2015)

Review Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Immunology

Metabolic Regulation of Immune Responses

Kirthana Ganeshan et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Review Immunology

gamma delta-T cells: an unpolished sword in human anti-infection immunity

Jian Zheng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2013)

Review Pharmacology & Pharmacy

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

Arian Emami Riedmaier et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2013)

Review Immunology

Six-of-the-best: unique contributions of γδ T cells to immunology

Pierre Vantourout et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Oncology

Diabetes and Cancer: A Consensus Report

Edward Giovannucci et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2010)

Review Immunology

γδ T cell subsets: A link between TCR and function?

Rebecca L. O'Brien et al.

SEMINARS IN IMMUNOLOGY (2010)

Review Immunology

γδ T cell effector functions: a blend of innate programming and acquired plasticity

Marc Bonneville et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Review Immunology

Innate immune functions of human gamma delta T cells

Susann Beetz et al.

IMMUNOBIOLOGY (2008)

Review Chemistry, Medicinal

Mechanisms of Action of Metformin in Type 2 Diabetes and Associated Complications: An Overview

Sonia Correia et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2008)

Review Immunology

Formation and function of the lytic NK-cell immunological synapse

Jordan S. Orange

NATURE REVIEWS IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity

Xi Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Immunology

Perforin-mediated target-cell death and immune homeostasis

Ilia Voskoboinik et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Review Immunology

The function of γδ T cells in innate immunity

WK Born et al.

CURRENT OPINION IN IMMUNOLOGY (2006)

Article Endocrinology & Metabolism

Incidence of type 1 and type 2 diabetes in adults aged 30-49 years

G Bruno et al.

DIABETES CARE (2005)

Article Medicine, General & Internal

Metformin and reduced risk of cancer in diabetic patients

JMM Evans et al.

BMJ-BRITISH MEDICAL JOURNAL (2005)

Review Pharmacology & Pharmacy

Activated T lymphocytes in type 2 diabetes:: Implications from in vitro studies

FB Stentz et al.

CURRENT DRUG TARGETS (2003)

Article Medicine, Research & Experimental

Role of AMP-activated protein kinase in mechanism of metformin action

GC Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)