Synthesis of 1,2-oxazetidines with a free -NH group via photoredox catalysis

A photoredox approach enabling one-step synthesis of oxazetidines with a free -NH group via the combined use of alkyne, thiophenol, and azide has been reported. The synthesized oxazetidine with the free -NH group was stable enough for various late-stage transformations such as methylation, acetylation, tosylation, and ring-opening reaction to afford synthetically useful alpha-aminoketones.

Automated summary

A new photoredox approach has been reported for the one-step synthesis of oxazetidines with a free -NH group, using the combined use of alkyne, thiophenol, and azide. The synthesized oxazetidine with the -NH group was found to be stable enough for various late-stage transformations.