Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 32, Pages 6293-6313Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00778a
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Funding
- National Natural Science Foundation of China [21871062, 22071035, 21961005]
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Quinazolinone and its derivatives are important structural units in pharmaceuticals and medicinal chemistry, exhibiting a wide range of biological and pharmacological activities. The synthesis strategies for 2,3-fused quinazolinone derivatives have made significant advances in recent years.
As one of the most important structural units in pharmaceuticals and medicinal chemistry, quinazolinone and its derivatives exhibit a wide range of biological and pharmacological activities, including anti-inflammatory, antitubercular, antiviral, and anticancer activities, etc. In particular, 2,3-fused quinazolinones have attracted much attention because the rings fused to the 2,3-positions of quinazolinones improve their rigidity and planarity. Their synthetic strategies have made great advances in recent years. Therefore, this review focuses on novel strategies for the synthesis of 2,3-fused quinazolinone derivatives from 2017 to 2022, such as the difunctionalization of alkenes, the ring-opening of easily available small rings, dehydrogenative cross-coupling reactions, transition-metal catalyzed cyclizations, cycloadditions, and other cascade reactions.
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