Journal
LANCET REGIONAL HEALTH-WESTERN PACIFIC
Volume 26, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.lanwpc.2022.100506
Keywords
Monoclonal antibodies (mAb); Fc-fusion protein; Biological medicine; Accessibility; Affordability; Unequal treatment access; Unmet needs; Healthcare systems; Healthcare professionals manpower; Asia Pacific
Funding
- NHMRC Project Grant [GNT1157506, GNT1196900]
- Enhanced Start-up Fund for new academic staff and Internal Research Fund, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong
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This study analyzed the consumption and expenditure trends of monoclonal antibodies (mAb) and Fc-fusion proteins (FcP) in 14 Asia-Pacific countries/regions and three benchmark countries. The findings show that while there have been significant increases in consumption and expenditure of these biologics, accessibility remains unequal and is largely correlated with the country's income level.
Background Monoclonal antibody (mAb) and Fc-fusion protein (FcP) are highly effective therapeutic biologics. We aimed to analyse consumption and expenditure trends in 14 Asia-Pacific countries/regions (APAC) and three benchmark countries (the UK, Canada, and the US). Methods We analysed 440 mAb and FcP biological products using the IQVIA-MIDAS global sales database. For each year between 2010 and 2020 inclusive, we used standard units (SU) sold per 1000 population and manufacture level price (standardised in 2019 US dollars) to evaluate consumption (accessibility) and expenditure (affordability). Changes of consumption and expenditure were estimated using compound annual growth rate (CAGR). Correlations between consumption, country's economic and health performance indicators were measured using Spearman correlation coefficient. Findings Between 2010 and 2020, CAGRs of consumption in each region ranged from 7% to 34% and the CAGRs of expenditure ranged from 9% to 31%. The median consumption of biologics was extremely low in lower-middle income economies (0.29 SU/1000 population) compared with upper-middle-income economies (1.20), high-income economies (40.94) and benchmark countries (109.55), although the median CAGRs of biologics consumption in lower-middle-income economies (31%) was greater than upper-middle-income (14%), high-income economies (13%) and benchmark countries (9%). Consumption was correlated with GDP per capita [Spearman's rank correlation coefficient (r) = 0.75, p < 0.001], health expenditure as a percentage of total (r = 0.83, p < 0.001) and medical doctors' density (r = 0.85, p < 0.001). Interpretation There have been significant increases in mAb and FcP biologics consumption and expenditure, however accessibility of biological medicines remains unequal and is largely correlated with country's income level. Copyright (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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