Journal
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
Volume 11, Issue 10, Pages 459-462Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jpids/piac063
Keywords
children; diarrhea; gastroenteritis; immunity; Nicaragua; norovirus
Categories
Funding
- National Institute of Allergy and Infectious Diseases [K24AI141744, R01AI127845, R01AI148260]
- NIH-Fogarty International Center [D43TW010923]
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Almost half of young children with norovirus GII infections had preexisting ligand-blocking antibodies to other GII genotypes, but these antibodies did not provide cross-protection within the GII genogroup.
Almost one-half of young children who experienced a norovirus GII episode had preexisting ligand-blocking antibodies to other GII genotypes tested (GII.4, GII.12, or GII.17). Our findings show that these heterotypic antibodies did not provide cross-protection within the GII genogroup. A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection.
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