Journal
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
Volume 11, Issue 10, Pages 463-466Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jpids/piac067
Keywords
acute gastroenteritis; antibodies; immunity; infants; multiplex Luminex assay; norovirus; vaccination
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Funding
- Fogarty International Center [D43TW010923]
- National Institute of Allergy and Infectious Diseases (NIAID) [R01AI127845, K24AI141744]
- National Institute of Allergy and Infectious Disease [R01AI148260]
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Infants are born with IgG antibodies to multiple norovirus genotypes, and the waning immunity necessitates the timing of pediatric norovirus vaccines. Antibody binding measurements in children can help guide the future administration of norovirus vaccines.
Infants are born with IgG antibodies to multiple norovirus genotypes; waning immunity appears consistent with infection risk. Pediatric norovirus vaccines should be administered when titers are low enough to avoid interference from maternally acquired antibodies, but before antibodies have completely waned. We measured antibody binding to diverse norovirus virus-like particles over 12 months in 16 children. All had maternal antibodies at 2 months, with estimated lowest levels at 5 months of age. Antibody increases after 3 months suggested natural infections. This information could guide the timing of future norovirus vaccines.
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