Journal
EXPRESS POLYMER LETTERS
Volume 16, Issue 9, Pages 933-938Publisher
BUDAPEST UNIV TECHNOL & ECON
DOI: 10.3144/expresspolymlett.2022.68
Keywords
tailor-made polymers; polymer molecular engineering; biocompatible polymers; poly(ethylene glycol) diamine; enzyme catalysis
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Funding
- Ohio State University
- Breast Cancer Innovation Foundation
- USDA-NIFA [OHO01417]
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This paper presents a new method for the amine-functionalization of PEG via CALB-catalyzed esterification, achieving full conversion for protected beta-Alanine but lower conversion for protected L-Alanine.
This paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of M-n = 2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected beta-Alanine and L-Alanine. NMR showed full conversion for protected beta-Alanine, and MALDI-ToF demonstrated the purity of the product. After deprotection, the desired diamine-functionalized PEG was obtained. Protected L-Alanine did not reach full conversion by NMR, likely due to the steric hindrance of its methyl side group.
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