Naringin is a promising natural compound for therapy of iron-overload disorders

Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. is being used Therefore, we provided 35 mice were classified into and they were divided into 5 five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then threated with normal saline (as control), naringin or DFO (n=7). Group A treated by normal saline, the others treated with iron dextran. After that group A and B treated with normal slaine, group C received desferal, group D and E received high and low dose of naringin respectively. Morphology changes, and iron deposition in liver tissues were studied using ME and Perlis staining.after The results revealed that naringin is more potent thant DFO in removing excessive iron ions deposited in liver tissues, indicating indication that naringin is a promising natural compound for therapy of iron overload disorders.

Automated summary

This study demonstrates that naringin exhibits satisfying iron chelation capacity and has the potential to be a promising natural substitute for the treatment of iron overload disorders.