The construction of phosphonate triazolyl by copper(ii)-catalyzed furan dearomatized [3+2] cycloaddition

Triazole phosphonates are valuable structural motifs in chemical biology and the subject of growing recent interest. A novel methodology to synthesize triazolyl phosphonates starting from furfuryl phosphonate alcohols and organo-azides was developed. This method involved an intermolecular copper-catalyzed dearomatized [3 + 2] cycloaddition/furan ring-opening cascade reaction. A strategy involving a three-component reaction was realized for quick access to triazole phosphonates.

Automated summary

Triazole phosphonates are important structural motifs in chemical biology and have gained increasing interest in recent years. A novel method to synthesize triazolyl phosphonates starting from furfuryl phosphonate alcohols and organo-azides using an intermolecular copper-catalyzed cascade reaction was developed. A three-component reaction strategy was realized for rapid access to triazole phosphonates.