Journal
BIOMATERIALS SCIENCE
Volume 10, Issue 19, Pages 5369-5390Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2bm00719c
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Funding
- Shanghai Sailing Program [21YF1431000, 22YF1417700]
- Open Research Fund Program of State Key Laboratory of Molecular Engineering of Polymers (Fudan University) [K2022-40]
- National Research Foundation of Korea - Korean government (MSIT) [2021R1A2C2003685]
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Porous organic polymers have attracted considerable attention due to their hierarchical pore structures, variable morphologies, and tunable biological properties. This review discusses the synthetic and post forming/control methods for controlling the hierarchical structures and morphologies of porous organic polymers, highlighting the different methods that affect their specific surface areas, hierarchical structures, and unique morphologies. Additionally, the applications of porous organic polymers in drug encapsulation and the development of stimuli-responsive materials are explored, focusing on their use for targeted drug release and as therapeutic agents.
Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials. In particular, their hierarchical pore structures, variable morphologies, and tunable biological properties make them suitable as drug-delivery systems. In this review, the synthetic and post forming/control methods including templated methods, template-free methods, mechanical methods, electrospun methods, and 3D printing methods for controlling the hierarchical structures and morphologies of porous organic polymers are discussed, and the different methods affecting their specific surface areas, hierarchical structures, and unique morphologies are highlighted in detail. In addition, we discuss their applications in drug encapsulation and the development of stimuli (pH, heat, light, and dual-stimuli)-responsive materials, focusing on their use for targeted drug release and as therapeutic agents. Finally, we present an outlook concerning the research directions and applications of porous polymer-based drug delivery systems.
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