3.8 Review

Hematopoietic stem cell mobilization

Related references

Note: Only part of the references are listed.
Article Hematology

FGF-23 from erythroblasts promotes hematopoietic progenitor mobilization

Shinichi Ishii et al.

Summary: FGF-23, produced by erythroblasts, plays a crucial role in G-CSF-induced hematopoietic progenitor cell mobilization by inhibiting chemoattraction, facilitating the release of HPCs from bone marrow into circulation.

BLOOD (2021)

Review Endocrinology & Metabolism

FGF23 signalling and physiology

Bryan B. Ho et al.

Summary: FGF23 is a phosphotropic hormone that undergoes post-translational modification by phosphorylation and O-glycosylation, which can lead to either proteolysis or secretion of biologically active intact forms. In the circulation, FGF23 may undergo further processing by other enzymes.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2021)

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Stem cells pack some chillis for the road

Anastasia N. Tikhonova et al.

NATURE (2021)

Article Multidisciplinary Sciences

Nociceptive nerves regulate haematopoietic stem cell mobilization

Xin Gao et al.

Summary: Nociceptive nerves play a role in enforcing HSC mobilization through CGRP secretion, collaborating with sympathetic nerves to maintain HSCs in the bone marrow. CGRP directly activates HSCs via the G alpha(s)/adenylyl cyclase/cAMP pathway, and consumption of capsaicin-containing food enhances HSC mobilization in mice.

NATURE (2021)

Review Cell Biology

Hematopoietic Stem Cell Niche During Homeostasis, Malignancy, and Bone Marrow Transplantation

Yan Man et al.

Summary: The self-renewal and differentiation of hematopoietic stem cells are tightly controlled by various cells and cytokines in the bone marrow microenvironment. Changes in the niche composition can lead to hematological malignancies, and processes like homing, proliferation, and differentiation of HSCs are crucial for the success of hematopoietic stem cell transplantation. Single-cell sequencing and in vivo imaging are powerful tools for studying the bone marrow microenvironment in diseases like leukemia and after transplantation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Editorial Material Hematology

FGF-23: a novel actor in stem cell mobilization

Laura M. Calvi

Summary: This study highlights the novel role of FGF-23 in G-CSF-stimulated mobilization of HSPCs, shedding light on the connection between phosphate metabolism and hematopoietic stem cells.

BLOOD (2021)

Review Hematology

Getting blood out of a stone: Identification and management of patients with poor hematopoietic cell mobilization

Jian Chen et al.

Summary: Hematopoietic cell transplantation (HCT) is a primary treatment for many cancers, with mobilization being the first essential step. Poor mobilization is a major factor affecting successful transplantation. Novel agents are being investigated to enhance mobilization response, and further understanding of the molecular mechanism of mobilization may lead to new therapeutic strategies for successful mobilization.

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The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood

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High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation

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Cellular players of hematopoietic stem cell mobilization in the bone marrow niche

Joshua Tay et al.

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Notch2 blockade enhances hematopoietic stem cell mobilization and homing

Weihuan Wang et al.

HAEMATOLOGICA (2017)

Editorial Material Medicine, Research & Experimental

Open the gates: vascular neurocrine signaling mobilizes hematopoietic stem and progenitor cells

Tomer Itkin et al.

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Neuropeptide Y regulates a vascular gateway for hematopoietic stem and progenitor cells

Pratibha Singh et al.

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Review Hematology

How to manage poor mobilizers for high dose chemotherapy and autologous stem cell transplantation?

Pinar Ataca Atilla et al.

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Notch2 blockade enhances hematopoietic stem cell mobilization and homing

Weihuan Wang et al.

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Innate Immunity and Mobilization of Hematopoietic Stem Cells

Mateusz Adamiak et al.

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Non-Hodgkin's Lymphomas, Version 3.2016 Featured Updates to the NCCN Guidelines

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Distinct bone marrow blood vessels differentially regulate haematopoiesis

Tomer Itkin et al.

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Mechanism and Regulation of NLRP3 Inflammasome Activation

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FGF-23 Is a Negative Regulator of Prenatal and Postnatal Erythropoiesis*

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Hematopoietic stem cell transplantation in SCD

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Chemokines and adult bone marrow stem cells

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Cooperation of beta(2)- and beta(3)-adrenergic receptors in hematopoietic progenitor cell mobilization

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Adrienne E. Dubin et al.

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Sterile inflammation: sensing and reacting to damage

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