Journal
TZU CHI MEDICAL JOURNAL
Volume 34, Issue 3, Pages 270-275Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/tcmj.tcmj_98_21
Keywords
Granulocyte colony-stimulating factor; Hematopoietic stem cell transplantation; Mobilization
Categories
Funding
- Ministry of Science and Technology, Taiwan [MOST 103-2321-B-320-001, MOST105-2633-B-320-001, MOST106-2633-B-320-001, MOST108-2311-B-320-001]
- Buddhist Tzu Chi Medical Foundation [TCMMP104-06, TCMMP108-04]
- Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan [TCRD106-42, TCRD108-55, TCRD110-61]
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Hematopoietic stem cell (HSC) transplantation is an effective method for treating hematopoietic diseases, with peripheral blood being the main source of HSCs. G-CSF and AMD3100 are commonly used methods to promote HSC mobilization, but alternative strategies are needed for poor mobilizers.
Hematopoietic stem cell (HSC) transplantation has been used to treat hematopoietic diseases for over 50 years. HSCs can be isolated from bone marrow (BM), umbilical cord blood, or peripheral blood. Because of lower costs, shorter hospitalization, and faster engraftment, peripheral blood has become the predominant source of HSCs for transplantation. The major factors determining the rate of successful HSC transplantation include the degree of human leukocyte antigen matching between the donor and recipient and the number of HSCs for transplantation. Administration of granulocyte colony-stimulating factor (G-CSF) alone or combined with plerixafor (AMD3100) are clinical used methods to promote HSC mobilization from BM to the peripheral blood for HSC transplantations. However, a significant portion of healthy donors or patients may be poor mobilizers of G-CSF, resulting in an insufficient number of HSCs for the transplantation and necessitating alternative strategies to increase the apheresis yield. The detailed mechanisms underlying G-CSF-mediated HSC mobilization remain to be elucidated. This review summarizes the current research on deciphering the mechanism of HSC mobilization.
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