Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study

Objective: The aim of this study was to explore interhemispheric intrinsic connectivity in patients with postherpetic neuralgia (PEN). Methods: We obtained resting-state functional magnetic resonance imaging data from 18 right-handed REIN patients (11 males, 7 females; mean age, 59.67 +/- 8.41 years) and 18 well -matched healthy controls (11 males, 7 females; mean age, 38.50 +/- 7.51 years). Interhemispheric connectivity was examined using voxel-mirrored homotopic connectivity (VMIIC), and seed-based functional connectivity analysis was performed. Results: Compared with the healthy controls, the patients with PHN showed abnormally decreased homotopic connectivity in the dorsolateral prefrontal cortex and the precuneus and posterior cingulate cortex (PC UN The decreased VMHC in the PC UN Vs was s positively correlated with the visual analog scale of PHN in the PHN patient group (rho=0.651; P=0.006). Receiver operating characteristic (ROC) analysis revealed that the areas under the curves for the two brain regions were 0.898 for the prefrontal cortex and 0.923 for the PC UN which indicated that the VMEIC could he used to discriminate RUN patients from healthy controls. A subsequent seed-based functional connectivity analysis revealed widely disrupted intrinsic connectivity between the regions that showed local homotopic connectivity deficits and the areas subservMg the default-mode network. Conclusion: Our results indicated reduced interhemispheric functional connectivity in patients with PHN, which seems to be an important new avenue to investigate to better understand the nature of disconnection of the functional architecture in patients with PHN.